A recent study indicates that patients who stop using popular GLP-1 drugs like Wegovy and Mounjaro may regain reduced body mass much more quickly than those who end traditional diet and exercise plans.
Findings released in a major health publication points out that while overweight people frequently drop about a fifth of their total mass while using the jabs, the mass returns at an average rate of 0.8 kg per month once they quit.
"Individuals buying such medications must be aware of the danger of rapid weight regain when the medication is stopped," stated expert Dr. Susan Jebb.
This pace of regain suggests a return to starting mass within about 18 months.
Analyzing Therapies
The study, which examined dozens of trials involving over 9,000 of patients, compared the effects of GLP-1 agonists with other pills.
The team note that individuals who shed pounds through dieting usually have a less rapid creep back—perhaps 100 grams monthly—once they finish.
Understanding the Fast Rebound
Nutrition scientists believe the mode of action of the jabs is key to understanding the heightened rebound.
These medications mimic a natural hormone called GLP-1, which helps regulate feelings of fullness.
"Artificially providing GLP-1 levels several times higher than normal may cause the body to generate a reduced amount of its own natural hormone, and may also reduce responsiveness to its effects," noted Dr. Adam Collins, a dietetics expert.
"Withdrawal of this GLP-1 'fix' means hunger is uncontrolled, making overeating much more probable."
An Ongoing Issue?
Medical guidelines advise the injections for individuals with weight-linked medical conditions, alongside prescribed diet and exercise modifications.
Professionals contend that, due to the likelihood of relapse, the treatment is often ongoing.
This perspective is supported by pharmaceutical companies, who note that the findings "emphasize the long-term nature of excess weight," comparing it to managing conditions like diabetes.
Patient Accounts
People who have stopped the jabs explain a powerful return of cravings.
"It was like something flipping and you're instantly ravenous," said one woman.
The struggle is compounded if individuals have not established lasting dietary or behavioural changes during treatment.
Widespread Use
Survey data indicate that a significant number of people in the UK have used weight-loss jabs in the last 12 months, with desire being substantial.
- Use is more common among women compared to men.
- The middle-aged age group shows the greatest level of interest.
- A large proportion obtain the drugs through private prescriptions rather than public health services.
Finally, clinicians caution that while the jabs are powerful tools for shedding pounds, they are not a standalone cure and long-term success likely depends on integrated behavioural management.
